RESEARCH

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper peptide that plays a critical role in tissue remodeling, wound healing, and cellular repair. It is composed of three amino acids (glycine, histidine, and lysine) bound to copper ions. GHK-Cu has been extensively studied for its potential to stimulate collagen production, regulate inflammation, and promote skin health and regeneration. GHK-Cu is provided in lyophilized powder form for research applications targeting cellular repair, skin health, and anti-inflammatory processes.

Chemical Information:

• Molecular Formula: C14H24N6O4Cu
• Molecular Weight: 340.84 g/mol*
• * “GHK-Cu may appear as ~340 Da (peptide only) or ~404 Da (copper complex) depending on MS conditions. The blue color confirms copper is present in the complex.”
• Sequence: Gly-His-Lys

Description:

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a synthetic copper peptide compound provided exclusively for in vitro research in qualified laboratory settings. It is composed of three amino acids (glycine, histidine, and lysine) bound to copper ions. This compound is intended solely for controlled experimental studies examining peptide-receptor interactions and cellular pathway analysis under laboratory conditions. Any research findings have not been evaluated by regulatory authorities and no claims regarding biological effects are made or implied.

Research Applications:

GHK-Cu is actively being researched for its potential to:

• Promote Wound Healing: Investigate its ability to enhance tissue repair and regeneration.
• Support Skin Health: Study its role in collagen synthesis and improving skin elasticity and texture.
• Regulate Inflammation: Explore its anti-inflammatory properties in both acute and chronic conditions.
• Encourage Hair Growth: Examine its effects on stimulating hair follicles and reducing hair loss.

Storage and Handling:

• Store lyophilized powder at -20°C.
• Once reconstituted, store at 2-8°C and use promptly.
• Maintain aseptic techniques during handling to ensure sterility.

Product Specifications:

• Purity: ≥99% (HPLC Certified)
• Appearance: Lyophilized white powder
• Solubility: Soluble in bacteriostatic water

Compliance Notice:

GHK-Cu is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for research purposes.

Key Benefits:

• Promotes collagen, elastin, and glycosaminoglycan synthesis → improves skin firmness and elasticity
• Accelerates wound and scar healing by enhancing fibroblast and keratinocyte activity
• Reduces inflammation and oxidative stress in skin and connective tissue
• Increases angiogenesis and microcirculation for improved nutrient delivery
• Activates regenerative genes associated with tissue remodeling and repair
• Improves skin tone, thickness, and overall youthfulness when used topically or systemically

Mechanism of Action (Simplified):

• Binds copper (II) ions → delivers bioavailable copper to cells for enzymatic activity
• Activates TGF-β and integrin pathways → stimulates fibroblast proliferation and ECM production
• Upregulates metalloproteinases (MMPs) for controlled tissue remodeling
• Down-regulates inflammatory cytokines (IL-6, TNF-α) → reduces inflammation and oxidative damage
• Increases VEGF and growth factor signaling → supports angiogenesis and repair

Applications / Possible Uses:

• Skin rejuvenation and anti-aging protocols
• Post-procedure recovery (microneedling, laser, PRP adjunct)
• Wound and scar healing research
• Hair follicle and scalp health improvement
• Systemic regenerative and antioxidant programs

Form / Notes:

• Lyophilized vial for reconstitution

Ideal for skincare and dermal repair formulations