Host Defense Peptide / Antimicrobial & Immune-Modulating Agent

LL-37 is a naturally occurring human cathelicidin peptide derived from the innate immune system.
It plays a central role in antimicrobial defense, inflammation control, and tissue repair.
LL-37 acts as both an antibiotic peptide and an immune modulator, providing broad-spectrum protection against bacteria, fungi, and viruses while promoting epithelial healing and immune balance.

RESEARCH

LL-37 is a naturally occurring antimicrobial peptide derived from the human cathelicidin protein. It is well-known for its ability to modulate immune responses, promote wound healing, and combat bacterial, viral, and fungal pathogens. LL-37 is provided in lyophilized powder form for research purposes exploring its role in immunity, inflammation, and tissue regeneration.

Chemical Information:

• Molecular Formula: C205H340N60O53
• Molecular Weight: 4492.11 g/mol
• Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH

Research Applications:

• Combat Pathogens: Investigate its antimicrobial properties against bacterial, viral, and fungal infections.
• Support Wound Healing: Study its ability to promote cellular repair and tissue regeneration in damaged areas.
• Regulate Immune Responses: Examine its role in modulating inflammatory pathways to enhance immune balance.
• Periodontal Disease: Explore its effectiveness in mitigating oral infections and promoting gum health in periodontal disease studies.

Storage and Handling:

• Store lyophilized powder at -20°C.
• Once reconstituted, store at 2-8°C and use promptly.
• Maintain aseptic techniques during handling to ensure sterility.

Product Specifications:

• Purity: ≥99% (HPLC Certified)
• Appearance: Lyophilized white powder
• Solubility: Soluble in bacteriostatic water

Compliance Notice:

LL-37 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

Key Benefits:

• Broad antimicrobial spectrum: active against Gram-positive and Gram-negative bacteria, fungi, and enveloped viruses
• Enhances innate immune response by activating macrophages and neutrophils
• Reduces inflammation via modulation of cytokine release (↓ IL-6, TNF-α)
• Promotes wound and tissue healing through angiogenesis and fibroblast activation
• Improves barrier integrity of skin, mucosa, and gut epithelium
• Synergistic with BPC-157, TB-500, and ARA-290 for total repair and immune protection

Mechanism of Action (Simplified):

• Binds microbial membranes → disrupts pathogen integrity and neutralizes endotoxins
• Activates innate immune cells via FPR2 and TLR pathways → improves pathogen clearance
• Regulates cytokine networks → balances inflammatory and healing responses
• Stimulates angiogenesis and epithelial repair in damaged tissue

Applications / Possible Uses:

• Antimicrobial and immune-modulation research
• Chronic wound, skin, and mucosal healing studies
• Inflammatory and autoimmune regulation models
• Synergistic use with TA1, Thymalin, and BPC-157 for integrated immune repair

Form / Notes:

Lyophilized 5 mg vial for reconstitution (typically 2–5 mL bacteriostatic water).
Used in research and advanced compounding for antimicrobial defense, immune regulation, and regenerative therapy development.