Melanotan 2 supports research into photoprotection, melanin synthesis, and neuroendocrine modulation, making it one of the most frequently studied peptides in pigmentation and melanocortin biology.

RESEARCH

Melanotan 2 is a laboratory-engineered peptide designed to mimic and enhance the biological activity of α-MSH, a key component of the melanocortin signaling pathway.
It has been extensively studied for its ability to stimulate melanin production, influence appetite and energy balance, and modulate sexual arousal pathways via melanocortin receptor activation.

Melanotan 2 is provided in lyophilized powder form for controlled in vitro and experimental model research focused on pigmentation biology, receptor signaling, and neuroendocrine response pathways.

Chemical Information:

Molecular Formula: C50H69N15O9
Molecular Weight: 1024.2 g/mol
Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (cyclic heptapeptide)

Melanotan 2 is a synthetic cyclic peptide designed exclusively for qualified laboratory research.
This compound is intended solely for in vitro experimental use in controlled settings.
The material is supplied in lyophilized powder form for structural, biochemical, and receptor-binding analysis.

No claims regarding biological activity, therapeutic effects, or clinical applications are made or implied.
Melanotan 2 is provided strictly for research studies related to melanocortin receptor activation, pigmentation signaling, and neuroendocrine pathways.

Research Applications:

Stimulate Melanin Production

Investigate MT-2’s ability to activate melanocortin-1 receptors and enhance melanin synthesis for pigmentation biology studies.

Support Photoprotection Research

Explore its role in increasing eumelanin levels, supporting research on UV-response and skin-cell photoprotection.

Examine Appetite and Energy Regulation

Study its interactions with MC3R and MC4R receptors involved in satiety, metabolic rate, and hypothalamic signaling.

Evaluate Sexual Function Pathways

Research its potential influence on neuroendocrine signaling associated with libido and arousal.

Analyze Anti-Inflammatory and Immunomodulatory Actions

Investigate its effects on melanocortin-mediated inflammatory pathways in cellular and molecular studies.

Storage and Handling:

• Store lyophilized powder at −20°C
• Once reconstituted, store at 2–8°C and use promptly
• Maintain aseptic technique during handling to ensure stability and sterility

Product Specifications:

Purity: ≥99% (HPLC Certified)
Appearance: Lyophilized white to off-white powder
Solubility: Soluble in bacteriostatic water

Compliance Notice:

Melanotan 2 is FOR RESEARCH USE ONLY.
It is not intended for human or veterinary use.
This product has not been evaluated by the FDA.
Misuse of this product is strictly prohibited and may violate federal, state, or local laws.
By purchasing this product, the buyer represents and warrants that it will be used only for in vitro research purposes.

Key Research Features:

• Activates melanocortin receptors (MC1R → pigmentation; MC3R/MC4R → energy balance)
• Supports melanin synthesis studies and UV-response modeling
• Influences neuroendocrine pathways connected to appetite, metabolism, and libido
• Exhibits antioxidant and photoprotective signaling effects in experimental systems
• Provides a stable, highly potent analog of endogenous α-MSH for controlled receptor studies

Mechanism of Action (Simplified):

1. Activates MC1R receptors → increases melanin production and pigmentation response
2. Stimulates MC3R/MC4R pathways → modulates appetite and energy expenditure signaling
3. Engages CNS melanocortin receptors → affects neuroendocrine outputs related to arousal
4. Enhances cellular stress response → supports antioxidant and photoprotective processes
5. Stabilized cyclic structure → increases receptor affinity and resistance to enzymatic breakdown

Applications / Possible Uses:

• Pigmentation and melanin pathway research
• UV-response and photoprotection studies
• Appetite and energy regulation modeling
• Neuroendocrine and hypothalamic signaling research
• Receptor binding and melanocortin system analysis
• Often paired with studies involving α-MSH, PT-141, or related melanocortin ligands

Form / Notes:

• Lyophilized vial for reconstitution
• Ideal for pigmentation, melanocortin, and neuroendocrine research studies
• Stable structure suitable for receptor-binding and signaling pathway assays