PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from the α-melanocyte-stimulating hormone (α-MSH) analog Melanotan II.

Unlike vascular-targeted agents, PT-141 functions primarily through central nervous system pathways, directly activating melanocortin receptors within the hypothalamus that regulate sexual arousal and motivation.

PT-141 is widely studied for its effects on libido enhancement, erectile response, sexual motivation, and neuroendocrine signaling in both male and female research models.

RESEARCH

PT-141 is a synthetic peptide analog of α-MSH designed to selectively activate melanocortin receptors involved in sexual function and energy regulation.

Research demonstrates that PT-141 primarily acts as an agonist at melanocortin-4 receptors (MC4R) and, to a lesser extent, melanocortin-1 receptors (MC1R). Activation of MC4R in the central nervous system has been associated with increased sexual arousal and motivation in preclinical and clinical research models.

Unlike phosphodiesterase-5 (PDE5) inhibitors that act peripherally on vascular smooth muscle, PT-141 exerts centrally mediated neuroendocrine effects, making it a distinct compound for research focused on CNS-driven sexual response pathways.

PT-141 is supplied in lyophilized powder form for controlled in vitro research applications involving melanocortin receptor activation, neuroendocrine signaling, and reproductive biology studies.

Chemical Information:

Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: 1025.2 g/mol
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
CAS Number: 189691-06-3
Structure: Cyclic heptapeptide melanocortin analog

Description:

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist supplied exclusively for qualified laboratory research.

This compound is intended solely for non-clinical, in vitro experimental use under controlled laboratory conditions.

Provided as a lyophilized powder, PT-141 is suitable for biochemical assays, receptor-binding analysis, neuroendocrine modeling, and melanocortin pathway research.

No claims regarding biological activity, therapeutic outcomes, or clinical applications are made or implied.

Research Applications:

Sexual Function & Libido Research

• Investigate centrally mediated sexual arousal pathways via MC4R activation.

Neuroendocrine Signaling Studies

• Examine hypothalamic receptor activation and downstream dopamine-related signaling.

Energy & Appetite Regulation Research

• Explore melanocortin receptor influence on metabolic and energy balance pathways.

Pigmentation & MC1R Studies

• Assess melanocyte activation and potential pigmentation signaling mechanisms.

Inflammatory & Immune Modulation Research

• Study melanocortin receptor involvement in anti-inflammatory signaling models.

Storage and Handling:

• Store lyophilized powder at −20°C
• Once reconstituted, store at 2–8°C and use promptly
• Maintain aseptic laboratory technique during handling

Product Specifications:

Purity: ≥99% (HPLC Certified)
Appearance: Lyophilized white powder
Solubility: Soluble in water or bacteriostatic water
Form: 10 mg vial

Compliance Notice:

PT-141 (Bremelanotide) is FOR RESEARCH USE ONLY.
It is not intended for human or veterinary use.
This product has not been evaluated by the FDA.
Misuse may violate federal, state, or local laws.

By purchasing this product, the buyer represents and warrants that it will be used solely for in vitro scientific research purposes.

Key Research Features:

• Selective melanocortin receptor agonist (MC4R primary target)
• Centrally acting compound influencing sexual arousal pathways
• Distinct from PDE5 inhibitors (non-vascular mechanism)
• Modulates neuroendocrine and dopamine-associated signaling
• Investigated for libido and sexual motivation in both male and female research models
• May exhibit mild MC1R-mediated pigmentation activity

Mechanism of Action (Simplified):

1. Agonizes melanocortin-4 receptors (MC4R) in the hypothalamus
   → enhances centrally mediated sexual arousal signaling
2. Modulates dopamine-associated neural circuits
   → supports motivation and reward pathway modeling
3. Bypasses nitric oxide–dependent vascular pathways
   → differentiates from PDE5 inhibitor research models
4. Secondary MC1R interaction
   → may influence pigmentation-related signaling
5. Engages neuroendocrine feedback systems
   → relevant for reproductive and hormonal research frameworks

Applications / Possible Uses:

• Sexual arousal and libido research (male and female models)
• Neuroendocrine and hypothalamic signaling studies
• Dopamine and reward pathway modeling
• Comparative studies vs Melanotan II and other melanocortin analogs
• Energy balance and melanocortin pathway research

Form / Notes:

• Lyophilized 10 mg vial for reconstitution
• Cyclic melanocortin analog derived from α-MSH
• Suitable for CNS-mediated arousal and melanocortin receptor research
• Commonly compared to Melanotan II, but optimized for MC4R-driven neuroendocrine signaling